{
  "edition": 1,
  "indexed": "2026-10-08",
  "scope": "Curated scoping index; not exhaustive or a full-text quality appraisal.",
  "sources": [
    {
      "id": "dx-001",
      "title": "Construction and iterative redesign of synXVI a 903\u2009kb synthetic Saccharomyces cerevisiae chromosome",
      "url": "https://www.nature.com/articles/s41467-024-55318-3",
      "publisher": "Nature Portfolio",
      "year": 2025,
      "type": "Primary study",
      "topic": "yeast",
      "summary": "Builds synthetic yeast chromosome XVI and documents design defects and repairs.",
      "limitation": "Does not preserve a human identity.",
      "doi": "10.1038/s41467-024-55318-3",
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-002",
      "title": "Towards the construction of a virtual yeast",
      "url": "https://www.nature.com/articles/s41586-026-10574-9",
      "publisher": "Nature Portfolio",
      "year": 2026,
      "type": "Perspective",
      "topic": "yeast",
      "summary": "Proposes an AI-driven virtual yeast linking biological data, models and experiments.",
      "limitation": "A research agenda, not a validated whole-cell simulation.",
      "doi": "10.1038/s41586-026-10574-9",
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-003",
      "title": "Systematic humanization of yeast genes reveals conserved functions and genetic modularity",
      "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4718922/",
      "publisher": "PubMed Central",
      "year": 2015,
      "type": "Primary study",
      "topic": "yeast",
      "summary": "Tests human genes as replacements for essential yeast genes.",
      "limitation": "Gene-function replacement is not transfer of traits or memories.",
      "doi": "10.1126/science.aaa0769",
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-004",
      "title": "Humanized yeast to model human biology, disease and evolution",
      "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC9194483/",
      "publisher": "PubMed Central",
      "year": 2022,
      "type": "Review",
      "topic": "yeast",
      "summary": "Reviews humanized yeast models of human gene function and disease variants.",
      "limitation": "Findings require context-specific validation.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-005",
      "title": "The adaptive molecular landscape of reprogrammed telomeric sequences",
      "url": "https://www.nature.com/articles/s41467-026-71475-z",
      "publisher": "Nature Portfolio",
      "year": 2026,
      "type": "Primary study",
      "topic": "yeast",
      "summary": "Examines molecular adaptation to human-like telomeric repeats in yeast.",
      "limitation": "Studies chromosome biology, not personal biological continuation.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-006",
      "title": "Saccharomyces Genome Database",
      "url": "https://www.yeastgenome.org/",
      "publisher": "SGD",
      "year": null,
      "type": "Database",
      "topic": "yeast",
      "summary": "Curated yeast genes, pathways, literature and analysis tools.",
      "limitation": "Reference annotations do not validate a proposed memorial culture.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-007",
      "title": "Iterative SCRaMbLE for engineering synthetic genome modules and chromosomes",
      "url": "https://www.nature.com/articles/s41467-025-62356-y",
      "publisher": "Nature Portfolio",
      "year": 2025,
      "type": "Primary study",
      "topic": "yeast",
      "summary": "Investigates iterative rearrangement of synthetic genome modules and chromosomes.",
      "limitation": "Genome engineering introduces stability and fitness tradeoffs.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-008",
      "title": "Debugging and consolidating multiple synthetic chromosomes reveals combinatorial genetic interactions",
      "url": "https://www.sciencedirect.com/science/article/pii/S0092867423010796",
      "publisher": "Elsevier",
      "year": 2023,
      "type": "Primary study",
      "topic": "yeast",
      "summary": "Combines synthetic chromosomes and investigates interacting design defects.",
      "limitation": "Viability is strain- and condition-dependent.",
      "doi": "10.1016/j.cell.2023.09.025",
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-009",
      "title": "Building synthetic chromosomes one yeast at a time: insights from Sc2.0",
      "url": "https://doi.org/10.1038/s41587-025-02913-4",
      "publisher": "Nature Biotechnology",
      "year": 2025,
      "type": "Commentary",
      "topic": "yeast",
      "summary": "Sc2.0 researchers reflect on synthetic yeast chromosome construction.",
      "limitation": "Consortium perspective; not evidence for the Culture.",
      "doi": "10.1038/s41587-025-02913-4",
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-010",
      "title": "Human Genome Reference Program (HGRP)",
      "url": "https://www.genome.gov/Funded-Programs-Projects/Human-Genome-Reference-Program",
      "publisher": "NHGRI",
      "year": null,
      "type": "Program",
      "topic": "genomes",
      "summary": "NHGRI explains efforts to improve human reference genomes.",
      "limitation": "A reference is not an individual's complete genome.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-011",
      "title": "A draft human pangenome reference",
      "url": "https://www.nature.com/articles/s41586-023-05896-x",
      "publisher": "Nature Portfolio",
      "year": 2023,
      "type": "Primary study",
      "topic": "genomes",
      "summary": "Introduces a diverse draft pangenome and compares variant detection with a single reference.",
      "limitation": "Does not eliminate all sequencing or interpretation gaps.",
      "doi": "10.1038/s41586-023-05896-x",
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-012",
      "title": "The complete sequence of a human genome",
      "url": "https://doi.org/10.1126/science.abj6987",
      "publisher": "Science / T2T Consortium",
      "year": 2022,
      "type": "Primary study",
      "topic": "genomes",
      "summary": "Reports the T2T consortium's gapless human reference sequence.",
      "limitation": "Not a complete account of every person's genetic variation.",
      "doi": "10.1126/science.abj6987",
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-013",
      "title": "Genome in a Bottle",
      "url": "https://www.nist.gov/programs-projects/genome-bottle",
      "publisher": "NIST",
      "year": null,
      "type": "Reference resource",
      "topic": "genomes",
      "summary": "NIST provides genome benchmarks and materials for evaluating sequencing accuracy.",
      "limitation": "Performance varies by region, variant class and reference version.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-014",
      "title": "Data Use",
      "url": "https://humanpangenome.org/data-use/",
      "publisher": "HPRC",
      "year": 2025,
      "type": "Guidance",
      "topic": "consent",
      "summary": "HPRC sets out ethical considerations for responsible pangenome data use.",
      "limitation": "Permissions remain dataset-specific.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-015",
      "title": "Genetic Testing FAQ",
      "url": "https://www.genome.gov/FAQ/Genetic-Testing",
      "publisher": "NHGRI",
      "year": null,
      "type": "Guidance",
      "topic": "consent",
      "summary": "NHGRI explains testing, potential consequences and limits of genetic-discrimination protection.",
      "limitation": "Results and legal protections are not comprehensive.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-016",
      "title": "Parallel molecular data storage by printing epigenetic bits on DNA",
      "url": "https://www.nature.com/articles/s41586-024-08040-5",
      "publisher": "Nature Portfolio",
      "year": 2024,
      "type": "Primary study",
      "topic": "dna-storage",
      "summary": "Demonstrates digital information written as methylation patterns on DNA templates.",
      "limitation": "Experimental encoding, not capture of biological memories.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal.",
      "dataLinks": [
        {
          "label": "Source data and code \u2014 Item 05",
          "url": "https://bdainformatics.org/dataRepository"
        }
      ]
    },
    {
      "id": "dx-017",
      "title": "Robust direct digital-to-biological data storage in living cells",
      "url": "https://www.nature.com/articles/s41589-020-00711-4",
      "publisher": "Nature Portfolio",
      "year": 2021,
      "type": "Primary study",
      "topic": "dna-storage",
      "summary": "Demonstrates direct digital-to-biological encoding in living cells.",
      "limitation": "Small-capacity laboratory work, not a human life archive.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-018",
      "title": "Towards practical and robust DNA-based data archiving using the yin\u2013yang codec system",
      "url": "https://www.nature.com/articles/s43588-022-00231-2",
      "publisher": "Nature Portfolio",
      "year": 2022,
      "type": "Primary study",
      "topic": "dna-storage",
      "summary": "Tests a DNA encoding system, including storage in yeast.",
      "limitation": "Long-term mutation and recovery require application-specific testing.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-019",
      "title": "Random access DNA memory using Boolean search in an archival file storage system",
      "url": "https://www.nature.com/articles/s41563-021-01021-3",
      "publisher": "Nature Portfolio",
      "year": 2021,
      "type": "Primary study",
      "topic": "dna-storage",
      "summary": "Demonstrates selective retrieval of DNA files using barcoded silica capsules.",
      "limitation": "A laboratory proof of concept, not a perpetual archive.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-020",
      "title": "Reversible DNA encapsulation in silica to produce ROS-resistant and heat-resistant synthetic DNA 'fossils'",
      "url": "https://www.nature.com/articles/nprot.2013.154",
      "publisher": "Nature Portfolio",
      "year": 2013,
      "type": "Methods",
      "topic": "dna-storage",
      "summary": "Describes protective silica encapsulation of DNA and subsequent recovery.",
      "limitation": "Tested protection does not establish indefinite preservation.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-021",
      "title": "DNA Fountain enables a robust and efficient storage architecture",
      "url": "https://pubmed.ncbi.nlm.nih.gov/28254941/",
      "publisher": "PubMed",
      "year": 2017,
      "type": "Primary study",
      "topic": "dna-storage",
      "summary": "Introduces an error-tolerant coding approach for DNA file storage and recovery.",
      "limitation": "Digital files require deliberate encoding and decoding.",
      "doi": "10.1126/science.aaj2038",
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-022",
      "title": "Advances and challenges in non-canonical nucleic acids data storage",
      "url": "https://www.nature.com/articles/s41467-026-68708-6",
      "publisher": "Nature Portfolio",
      "year": 2026,
      "type": "Review",
      "topic": "dna-storage",
      "summary": "Surveys non-canonical nucleic-acid storage and preservation challenges.",
      "limitation": "Emerging approaches have application-specific limits.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-023",
      "title": "Scalable and robust DNA-based storage via coding theory and deep learning",
      "url": "https://www.nature.com/articles/s42256-025-01003-z",
      "publisher": "Nature Portfolio",
      "year": 2025,
      "type": "Primary study",
      "topic": "dna-storage",
      "summary": "Combines coding theory and deep learning for DNA-storage information retrieval.",
      "limitation": "Performance is dataset-specific; an author correction is available.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-024",
      "title": "Molecular digital data storage using DNA",
      "url": "https://www.nature.com/articles/s41576-019-0125-3",
      "publisher": "Nature Portfolio",
      "year": 2019,
      "type": "Review",
      "topic": "dna-storage",
      "summary": "Surveys molecular data storage architectures and technical bottlenecks.",
      "limitation": "Foundational overview; newer work extends the field.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-025",
      "title": "A conserved interdomain microbial network underpins cadaver decomposition despite environmental variables",
      "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10914610/",
      "publisher": "PubMed Central",
      "year": 2024,
      "type": "Primary study",
      "topic": "decomposition",
      "summary": "Identifies interacting decomposer communities across human cadavers in different environments.",
      "limitation": "Does not establish complete conversion by a single yeast strain.",
      "doi": "10.1038/s41564-023-01580-y",
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-026",
      "title": "16S rRNA, metagenomics and 2bRAD-M sequencing to decode human thanatomicrobiome",
      "url": "https://www.nature.com/articles/s41597-024-03518-3",
      "publisher": "Nature Portfolio",
      "year": 2024,
      "type": "Dataset paper",
      "topic": "decomposition",
      "summary": "Compares microbial sequencing across tissues and decomposition stages in eight cadavers.",
      "limitation": "Small cohort; method performance varies by sample.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-027",
      "title": "Quantifying the relative contributions of bacterial and fungal communities to carcass decomposition using a quantitative microbiome profiling approach",
      "url": "https://www.nature.com/articles/s41522-025-00842-3",
      "publisher": "Nature Portfolio",
      "year": 2025,
      "type": "Primary study",
      "topic": "decomposition",
      "summary": "Quantifies bacterial and fungal communities during carcass decomposition.",
      "limitation": "Carcass evidence does not validate a human disposition service.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-028",
      "title": "Human Composting Soil Research",
      "url": "https://recompose.life/human-composting/soil-research-pilot-study/",
      "publisher": "Recompose / WSU pilot",
      "year": 2018,
      "type": "Provider report",
      "topic": "decomposition",
      "summary": "Reports a six-donor natural organic reduction pilot conducted with Washington State University.",
      "limitation": "Sponsor-hosted summary; not evidence for engineered-yeast conversion.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-029",
      "title": "Functional and Structural Succession of Soil Microbial Communities below Decomposing Human Cadavers.",
      "url": "https://pubmed.ncbi.nlm.nih.gov/26067226/",
      "publisher": "PubMed",
      "year": 2015,
      "type": "Primary study",
      "topic": "soil",
      "summary": "Examines soil microbial structure and function beneath decomposing human cadavers.",
      "limitation": "Does not establish tree survival or site suitability.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-030",
      "title": "Soil elemental changes during human decomposition",
      "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10263346/",
      "publisher": "PubMed Central",
      "year": 2023,
      "type": "Primary study",
      "topic": "soil",
      "summary": "Measures dissolved soil elements during a four-month human decomposition study.",
      "limitation": "Nutrient release is not equivalent to safe planting conditions.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-031",
      "title": "Exploring DNA degradation in situ and in museum storage through genomics and metagenomics",
      "url": "https://www.nature.com/articles/s42003-025-07616-9",
      "publisher": "Nature Portfolio",
      "year": 2025,
      "type": "Primary study",
      "topic": "biobanking",
      "summary": "Compares DNA preservation in archaeological bones with different excavation and storage histories.",
      "limitation": "Not a universal shelf-life estimate for banked human samples.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-032",
      "title": "Investigating ancient human DNA preservation on cave walls and in rock art",
      "url": "https://www.nature.com/articles/s41467-026-74234-2",
      "publisher": "Nature Portfolio",
      "year": 2026,
      "type": "Primary study",
      "topic": "biobanking",
      "summary": "Investigates ancient human DNA in cave-wall pigments and rock-art environments.",
      "limitation": "Trace survival does not imply intact genomes or preserved memories.",
      "doi": "10.1038/s41467-026-74234-2",
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-033",
      "title": "Best Practices for Biospecimen Resources - NCI",
      "url": "https://dctd.cancer.gov/data-tools-biospecimens/biospecimens-biobanks/resources/best-practices/biospecimen-resources",
      "publisher": "National Cancer Institute",
      "year": 2026,
      "type": "Guidance",
      "topic": "biobanking",
      "summary": "NCI's fourth-edition practices cover biospecimen operations, quality and governance.",
      "limitation": "Guidance, not certification of Death X.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-034",
      "title": "Technical and Operational Best Practices - NCI",
      "url": "https://dctd.cancer.gov/data-tools-biospecimens/biospecimens-biobanks/resources/best-practices/biospecimen-resources/technical-operational",
      "publisher": "National Cancer Institute",
      "year": 2026,
      "type": "Guidance",
      "topic": "biobanking",
      "summary": "Addresses sample collection, storage, retrieval, quality controls and operations.",
      "limitation": "Local procedures still require validation.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-035",
      "title": "Governance Best Practices - NCI",
      "url": "https://dctd.cancer.gov/data-tools-biospecimens/biospecimens-biobanks/resources/best-practices/biospecimen-resources/ethical-legal",
      "publisher": "National Cancer Institute",
      "year": 2026,
      "type": "Guidance",
      "topic": "consent",
      "summary": "Covers biospecimen custodianship, consent, privacy, access and legacy planning.",
      "limitation": "Not a substitute for participant-specific consent.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-036",
      "title": "ISBER Best Practices For Repositories - ISBER",
      "url": "https://www.isber.org/page/BPR",
      "publisher": "ISBER",
      "year": 2023,
      "type": "Guidance",
      "topic": "biobanking",
      "summary": "ISBER repository practices address sample stewardship and quality management.",
      "limitation": "Cannot guarantee indefinite sample integrity.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-037",
      "title": "Vitrification and nanowarming enable long-term organ cryopreservation and life-sustaining kidney transplantation in a rat model",
      "url": "https://www.nature.com/articles/s41467-023-38824-8",
      "publisher": "Nature Portfolio",
      "year": 2023,
      "type": "Primary study",
      "topic": "biobanking",
      "summary": "Demonstrates vitrification, nanowarming and life-supporting transplantation of rat kidneys.",
      "limitation": "Animal-organ results do not show human whole-body revival.",
      "doi": "10.1038/s41467-023-38824-8",
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-038",
      "title": "Ultrastructure of human brain tissue vitrified from autopsy revealed by cryo-ET with cryo-plasma FIB milling",
      "url": "https://www.nature.com/articles/s41467-024-47066-1",
      "publisher": "Nature Portfolio",
      "year": 2024,
      "type": "Primary study",
      "topic": "biobanking",
      "summary": "Uses vitrified autopsy brain tissue for cryo-electron tomography.",
      "limitation": "Preserved structure does not show recovered consciousness.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-039",
      "title": "Effective cryopreservation of human brain tissue and neural organoids",
      "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC11133841/",
      "publisher": "PubMed Central",
      "year": 2024,
      "type": "Primary study",
      "topic": "biobanking",
      "summary": "Investigates cryopreservation of human brain tissue and neural organoids.",
      "limitation": "Tissue preservation is not whole-person preservation.",
      "doi": "10.1016/j.crmeth.2024.100777",
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-040",
      "title": "Pancreatic islet cryopreservation by vitrification achieves high viability, function, recovery and clinical scalability for transplantation",
      "url": "https://www.nature.com/articles/s41591-022-01718-1",
      "publisher": "Nature Portfolio",
      "year": 2022,
      "type": "Primary study",
      "topic": "biobanking",
      "summary": "Studies vitrification and functional recovery of pancreatic islets.",
      "limitation": "Cannot be extrapolated to whole brains or people.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-041",
      "title": "Nanowarming and ice-free cryopreservation of large sized, intact porcine articular cartilage",
      "url": "https://www.nature.com/articles/s42003-023-04577-9",
      "publisher": "Nature Portfolio",
      "year": 2023,
      "type": "Primary study",
      "topic": "biobanking",
      "summary": "Studies ice-free preservation and nanowarming of porcine cartilage.",
      "limitation": "Tissue-specific results need separate validation in other organs.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-042",
      "title": "Functional recovery of the adult murine hippocampus after cryopreservation by vitrification",
      "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC12974479/",
      "publisher": "PubMed Central",
      "year": 2026,
      "type": "Primary study",
      "topic": "brain",
      "summary": "Reports short-term recovery of hippocampal electrophysiological function after vitrification in mice.",
      "limitation": "Does not establish animal revival or recovery of autobiographical memories.",
      "doi": "10.1073/pnas.2516848123",
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-043",
      "title": "Systems consolidation reorganizes hippocampal engram circuitry",
      "url": "https://www.nature.com/articles/s41586-025-08993-1",
      "publisher": "Nature Portfolio",
      "year": 2025,
      "type": "Primary study",
      "topic": "brain",
      "summary": "Studies hippocampal engram circuit reorganization during memory consolidation.",
      "limitation": "Not a method to extract a person's life memories.",
      "doi": "10.1038/s41586-025-08993-1",
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-044",
      "title": "Functional connectomics spanning multiple areas of mouse visual cortex",
      "url": "https://www.nature.com/articles/s41586-025-08790-w",
      "publisher": "Nature Portfolio",
      "year": 2025,
      "type": "Dataset paper",
      "topic": "brain",
      "summary": "MICrONS links neuronal activity with dense wiring maps in mouse visual cortex.",
      "limitation": "Partial mouse cortex, not a whole human mind.",
      "doi": "10.1038/s41586-025-08790-w",
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal.",
      "dataLinks": [
        {
          "label": "MICrONS cortical mm\u00b3 dataset",
          "url": "https://www.micronsexplorer.org/cortical-mm3"
        },
        {
          "label": "BossDB dataset",
          "url": "https://bossdb.org/project/microns-minnie"
        },
        {
          "label": "Analysis code \u2014 Allen Institute",
          "url": "https://github.com/AllenInstitute/MicronsFunctionalConnectomics"
        }
      ]
    },
    {
      "id": "dx-045",
      "title": "A petavoxel fragment of human cerebral cortex reconstructed at nanoscale resolution",
      "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC11718559/",
      "publisher": "PubMed Central",
      "year": 2024,
      "type": "Dataset paper",
      "topic": "brain",
      "summary": "Reconstructs a small fragment of human cerebral cortex at nanoscale resolution.",
      "limitation": "Tissue mapping does not decode personal memories.",
      "doi": "10.1126/science.adk4858",
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-046",
      "title": "Semantic reconstruction of continuous language from non-invasive brain recordings",
      "url": "https://www.nature.com/articles/s41593-023-01304-9",
      "publisher": "Nature Portfolio",
      "year": 2023,
      "type": "Primary study",
      "topic": "brain",
      "summary": "Reconstructs aspects of language from subject-specific non-invasive brain recordings.",
      "limitation": "Requires living participants and training; not post-mortem memory retrieval.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-047",
      "title": "Astroengrams: rethinking the cellular substrate for memory",
      "url": "https://www.nature.com/articles/s41583-025-01012-2",
      "publisher": "Nature Portfolio",
      "year": 2026,
      "type": "Perspective",
      "topic": "brain",
      "summary": "Discusses astrocyte ensembles and an expanded view of memory engrams.",
      "limitation": "A framework, not an identity-preservation technology.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-048",
      "title": "Restoration of brain circulation and cellular functions hours post-mortem",
      "url": "https://www.nature.com/articles/s41586-019-1099-1",
      "publisher": "Nature Portfolio",
      "year": 2019,
      "type": "Primary study",
      "topic": "brain",
      "summary": "Restores circulation and selected cellular functions in isolated pig brains after death.",
      "limitation": "Cellular function is not evidence of restored consciousness.",
      "doi": "10.1038/s41586-019-1099-1",
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-049",
      "title": "Levels of Digital Preservation",
      "url": "https://www.ndsa.org/activities/levels-of-digital-preservation/",
      "publisher": "NDSA",
      "year": 2026,
      "type": "Standard",
      "topic": "digital-archives",
      "summary": "NDSA Levels of Digital Preservation offers a staged framework; version 2.1 includes sustainability.",
      "limitation": "A maturity framework, not a perpetual-access guarantee.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-050",
      "title": "Recommended Formats Statement - Resources (Preservation, Library of Congress)",
      "url": "https://www.loc.gov/preservation/resources/rfs/index.html",
      "publisher": "Library of Congress",
      "year": 2025,
      "type": "Standard",
      "topic": "digital-archives",
      "summary": "Library of Congress 2025\u20132026 format recommendations address long-term access.",
      "limitation": "Institutional preferences need adaptation to sensitive private archives.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-051",
      "title": "Digital Formats",
      "url": "https://www.loc.gov/programs/digital-collections-management/digital-formats/",
      "publisher": "Library of Congress",
      "year": null,
      "type": "Guidance",
      "topic": "digital-archives",
      "summary": "Explains Library of Congress digital-format management and preservation decisions.",
      "limitation": "Formats do not solve custody, access or funding.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-052",
      "title": "The BagIt File Packaging Format (RFC 8493)",
      "url": "https://www.rfc-editor.org/rfc/rfc8493.html",
      "publisher": "RFC Editor",
      "year": 2018,
      "type": "Standard",
      "topic": "digital-archives",
      "summary": "BagIt specifies collection packaging and manifests for transfer and integrity checks.",
      "limitation": "Checksums alone do not supply backups or confidentiality.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-053",
      "title": "Sustainability of Digital Formats: Planning for Library of Congress Collections",
      "url": "https://loc.gov/preservation/digital/formats/index.shtml",
      "publisher": "Library of Congress",
      "year": null,
      "type": "Reference resource",
      "topic": "digital-archives",
      "summary": "Library of Congress documents file formats and preservation characteristics.",
      "limitation": "Suitability depends on content and preservation requirements.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-054",
      "title": "Personal Digital Archiving",
      "url": "https://www.digitalpreservation.gov/personalarchiving/",
      "publisher": "Library of Congress",
      "year": null,
      "type": "Guidance",
      "topic": "digital-archives",
      "summary": "Practical advice for preserving personal digital photos, recordings and documents.",
      "limitation": "A managed archive also needs ownership and succession plans.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-055",
      "title": "Personal Digital Records - Personal Archiving",
      "url": "https://digitalpreservation.gov/personalarchiving/records.html",
      "publisher": "Library of Congress",
      "year": null,
      "type": "Guidance",
      "topic": "digital-archives",
      "summary": "Explains how to organize and retain important personal digital records.",
      "limitation": "Copies remain vulnerable without a tested preservation plan.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-056",
      "title": "The FAIR Guiding Principles for scientific data management and stewardship",
      "url": "https://www.nature.com/articles/sdata201618",
      "publisher": "Nature Portfolio",
      "year": 2016,
      "type": "Standard",
      "topic": "digital-archives",
      "summary": "FAIR principles address findable, accessible, interoperable and reusable research data.",
      "limitation": "FAIR does not require public release of sensitive information.",
      "doi": "10.1038/sdata.2016.18",
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-057",
      "title": "Coral reef restoration monitoring guide: Methods to evaluate restoration success from local to ecosystem scales - NCCOS - National Centers for Coastal Ocean Science",
      "url": "https://coastalscience.noaa.gov/data_reports/coral-reef-restoration-monitoring-guide-methods-to-evaluate-restoration-success-from-local-to-ecosystem-scales/",
      "publisher": "NOAA",
      "year": null,
      "type": "Guidance",
      "topic": "reef",
      "summary": "NOAA describes how to assess coral-restoration outcomes across scales.",
      "limitation": "Projects need site-specific baselines and follow-up.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-058",
      "title": "NCRMP",
      "url": "https://www.coralreef.noaa.gov/topics/national-coral-reef-monitoring-program",
      "publisher": "NOAA",
      "year": null,
      "type": "Program",
      "topic": "reef",
      "summary": "NOAA integrates biological and environmental coral-reef observations.",
      "limitation": "Monitoring data is not approval for a memorial reef.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-059",
      "title": "NOAA Coral Reef Watch Homepage and Near Real-Time Products Portal",
      "url": "https://coralreefwatch.noaa.gov/",
      "publisher": "NOAA",
      "year": null,
      "type": "Database",
      "topic": "reef",
      "summary": "NOAA Coral Reef Watch provides near-real-time coral heat-stress monitoring.",
      "limitation": "Heat indicators are not survival guarantees.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-060",
      "title": "NCRMP",
      "url": "https://www.coralreef.noaa.gov/topics/national-coral-reef-monitoring-program/protocols",
      "publisher": "NOAA",
      "year": null,
      "type": "Methods",
      "topic": "reef",
      "summary": "NOAA provides consistent coral-reef monitoring protocols.",
      "limitation": "Survey design and permits remain project-specific.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-061",
      "title": "Artificial reef footprint in the United States ocean",
      "url": "https://www.nature.com/articles/s41893-023-01258-7",
      "publisher": "Nature Portfolio",
      "year": 2024,
      "type": "Primary study",
      "topic": "reef",
      "summary": "Quantifies artificial-reef seafloor footprint across US ocean reefing programs.",
      "limitation": "Reef area alone does not measure ecological benefit.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-062",
      "title": "Artificial structures can facilitate rapid coral recovery under climate change",
      "url": "https://www.nature.com/articles/s41598-025-93531-2",
      "publisher": "Nature Portfolio",
      "year": 2025,
      "type": "Primary study",
      "topic": "reef",
      "summary": "Examines long-term coral cover on artificial structures and natural reefs in Okinawa.",
      "limitation": "Local recovery does not establish equivalent biodiversity everywhere.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-063",
      "title": "The natural architecture of oyster reefs maximizes recruit survival",
      "url": "https://www.nature.com/articles/s41586-026-10103-8",
      "publisher": "Nature Portfolio",
      "year": 2026,
      "type": "Primary study",
      "topic": "reef",
      "summary": "Tests how oyster-reef geometry influences settlement, predation and survival.",
      "limitation": "Does not validate materials containing human remains.",
      "doi": "10.1038/s41586-026-10103-8",
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal.",
      "dataLinks": [
        {
          "label": "Oyster complexity \u2014 data and analysis code",
          "url": "https://github.com/juan-muelbert/Oyster-complexity"
        }
      ]
    },
    {
      "id": "dx-064",
      "title": "Ocean heat determines benthic trajectories on artificial as well as natural submarine substrata",
      "url": "https://www.nature.com/articles/s41598-025-31135-6",
      "publisher": "Nature Portfolio",
      "year": 2025,
      "type": "Primary study",
      "topic": "reef",
      "summary": "Tracks artificial and natural substrates under repeated ocean heat stress.",
      "limitation": "Artificial habitats remain exposed to climate pressures.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-065",
      "title": "Restoration cannot be scaled up globally to save reefs from loss and degradation",
      "url": "https://www.nature.com/articles/s41559-025-02667-x",
      "publisher": "Nature Portfolio",
      "year": 2025,
      "type": "Research synthesis",
      "topic": "reef",
      "summary": "Examines limits of scaling restoration to offset global reef degradation.",
      "limitation": "Local success is not a global climate solution.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-066",
      "title": "Artificial Reefs",
      "url": "https://myfwc.com/fishing/saltwater/artificial-reefs/",
      "publisher": "Florida FWC",
      "year": null,
      "type": "Program",
      "topic": "reef",
      "summary": "Florida FWC provides artificial-reef information and program resources.",
      "limitation": "Not a permit for a specific installation.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-067",
      "title": "Burial at Sea",
      "url": "https://www.epa.gov/marine-protection-permitting/burial-sea",
      "publisher": "US EPA",
      "year": null,
      "type": "Regulation",
      "topic": "regulation",
      "summary": "EPA explains burial-at-sea permit conditions and excluded activities, including artificial reef placement.",
      "limitation": "A memorial reef needs a separate established legal pathway.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-068",
      "title": "WAC 246-500-055:",
      "url": "https://apps.leg.wa.gov/wac/default.aspx?cite=246-500-055",
      "publisher": "Washington State",
      "year": null,
      "type": "Regulation",
      "topic": "regulation",
      "summary": "Washington specifies testing, sampling and records for natural organic reduction output.",
      "limitation": "Does not authorize a new process elsewhere.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-069",
      "title": "RCW 68.04.020:",
      "url": "https://apps.leg.wa.gov/rcw/default.aspx?cite=68.04.020",
      "publisher": "Washington State",
      "year": null,
      "type": "Regulation",
      "topic": "regulation",
      "summary": "Washington defines remains to include cremation, hydrolysis and natural organic reduction.",
      "limitation": "A definition is not a license or authorization.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-070",
      "title": "\u00a7 7\u2013231.17. Final disposition of dead body or fetus.",
      "url": "https://code.dccouncil.gov/us/dc/council/code/sections/7-231.17",
      "publisher": "DC Council",
      "year": null,
      "type": "Regulation",
      "topic": "regulation",
      "summary": "DC specifies disposition authorizations, permits and required death documentation.",
      "limitation": "Does not establish authorization for the Culture.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-071",
      "title": "\u00a7 3\u2013402. Definitions.",
      "url": "https://code.dccouncil.gov/us/dc/council/code/sections/3-402",
      "publisher": "DC Council",
      "year": null,
      "type": "Regulation",
      "topic": "regulation",
      "summary": "DC defines regulated funeral roles, establishments and human remains.",
      "limitation": "Read alongside the full applicable law.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-072",
      "title": "Complying with the Funeral Rule",
      "url": "https://www.ftc.gov/business-guidance/resources/complying-funeral-rule",
      "publisher": "FTC",
      "year": null,
      "type": "Guidance",
      "topic": "regulation",
      "summary": "FTC explains itemized funeral-price disclosures and covered pre-need arrangements.",
      "limitation": "A membership table is not an itemized General Price List.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-073",
      "title": "The FTC Funeral Rule",
      "url": "https://consumer.ftc.gov/articles/ftc-funeral-rule",
      "publisher": "FTC",
      "year": null,
      "type": "Guidance",
      "topic": "regulation",
      "summary": "FTC explains consumers' rights to choose funeral goods and services individually.",
      "limitation": "Applicability depends on the provider and offering.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-074",
      "title": "Comprehensive clearance search for similar trademarks",
      "url": "https://www.uspto.gov/trademarks/search/comprehensive-clearance-search-similar-trademarks",
      "publisher": "USPTO",
      "year": null,
      "type": "Guidance",
      "topic": "regulation",
      "summary": "USPTO explains searches for confusingly similar trademarks.",
      "limitation": "A domain or exact-name search does not establish clearance.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-075",
      "title": "Search our trademark database",
      "url": "https://www.uspto.gov/trademarks/search",
      "publisher": "USPTO",
      "year": null,
      "type": "Reference resource",
      "topic": "regulation",
      "summary": "USPTO provides federal trademark search tools and guidance.",
      "limitation": "Federal records are one part of a broader clearance review.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-076",
      "title": "TSCA Biotechnology Regulations",
      "url": "https://www.epa.gov/regulation-biotechnology-under-tsca-and-fifra/tsca-biotechnology-regulations",
      "publisher": "US EPA",
      "year": null,
      "type": "Regulation",
      "topic": "biosafety",
      "summary": "EPA explains TSCA review for certain new microorganisms.",
      "limitation": "Applicability depends on organism, use and release scenario.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-077",
      "title": "Biosafety in Microbiological and Biomedical Laboratories (BMBL) 6th Edition",
      "url": "https://www.cdc.gov/labs/bmbl/index.html",
      "publisher": "CDC / NIH",
      "year": 2020,
      "type": "Guidance",
      "topic": "biosafety",
      "summary": "CDC and NIH's sixth-edition BMBL emphasizes risk assessment and containment.",
      "limitation": "Advisory biosafety guidance, not product approval.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-078",
      "title": "4.1.27 Research Involving Recombinant or Synthetic Nucleic Acid Molecules (including Human Gene Transfer Research)",
      "url": "https://www.grants.nih.gov/grants/policy/nihgps/HTML5/section_4/4.1.27_research_involving_recombinant_or_synthetic_nucleic_acid_molecules__including_human_gene_transfer_research_.htm",
      "publisher": "NIH",
      "year": 2026,
      "type": "Guidance",
      "topic": "biosafety",
      "summary": "NIH explains applicability of recombinant and synthetic nucleic-acid guidelines.",
      "limitation": "Institutional and funding circumstances affect applicability.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-079",
      "title": "NOT-OD-25-082: Implementation Update: Promoting Maximal Transparency Under the NIH Guidelines for Research Involving Recombinant or Synthetic Nucleic Acid Molecules",
      "url": "https://www.grants.nih.gov/grants/guide/notice-files/NOT-OD-25-082.html",
      "publisher": "NIH",
      "year": 2025,
      "type": "Guidance",
      "topic": "biosafety",
      "summary": "NIH clarifies transparency expectations for institutional biosafety committees.",
      "limitation": "Not authorization for environmental release.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-080",
      "title": "Design and regulation of engineered bacteria for environmental release",
      "url": "https://www.nature.com/articles/s41564-024-01918-0",
      "publisher": "Nature Portfolio",
      "year": 2025,
      "type": "Review",
      "topic": "biosafety",
      "summary": "Reviews engineering and regulation of microbes intended for environmental release.",
      "limitation": "Laboratory performance does not establish environmental safety.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-081",
      "title": "Advances in biocontainment strategies of engineered microbes for use in humans",
      "url": "https://www.sciencedirect.com/science/article/pii/S1369527426000214",
      "publisher": "Elsevier",
      "year": 2026,
      "type": "Review",
      "topic": "biosafety",
      "summary": "Surveys containment approaches for engineered microbes used in humans.",
      "limitation": "Strategies require organism-specific validation.",
      "doi": "10.1016/j.mib.2026.102727",
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-082",
      "title": "Griefbots, Deadbots, Postmortem Avatars: On Responsible Applications of Generative AI in the Digital Afterlife Industry",
      "url": "https://www.repository.cam.ac.uk/items/bc2f1612-f989-4a92-9d1a-7105a3757d7b",
      "publisher": "University of Cambridge",
      "year": 2024,
      "type": "Ethics research",
      "topic": "consent",
      "summary": "Examines consent, transparency and retirement of AI simulations of deceased people.",
      "limitation": "Ethical analysis, not evidence of benefit or identity preservation.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-083",
      "title": "Identifying personal genomes by surname inference",
      "url": "https://pubmed.ncbi.nlm.nih.gov/23329047/",
      "publisher": "PubMed",
      "year": 2013,
      "type": "Primary study",
      "topic": "consent",
      "summary": "Demonstrates re-identification using genetic genealogy and other information.",
      "limitation": "Removing names does not ensure genomic privacy.",
      "doi": "10.1126/science.1229566",
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-084",
      "title": "Privacy Framework",
      "url": "https://www.nist.gov/privacy-framework",
      "publisher": "NIST",
      "year": null,
      "type": "Framework",
      "topic": "consent",
      "summary": "NIST's Privacy Framework structures privacy risk management.",
      "limitation": "Voluntary framework, not proof of compliance.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-085",
      "title": "CSWP 40, NIST Privacy Framework 1.1",
      "url": "https://csrc.nist.gov/pubs/cswp/40/nist-privacy-framework-11/ipd",
      "publisher": "NIST",
      "year": 2025,
      "type": "Draft framework",
      "topic": "consent",
      "summary": "NIST's initial public draft of Privacy Framework 1.1 proposes updates.",
      "limitation": "This linked version is a draft.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-086",
      "title": "Data Security Work Stream \u2013 GA4GH",
      "url": "https://www.ga4gh.org/work_stream/data-security/",
      "publisher": "GA4GH",
      "year": null,
      "type": "Program",
      "topic": "consent",
      "summary": "GA4GH develops security standards for genomic data exchange.",
      "limitation": "Requires sound implementation and governance.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-087",
      "title": "Home - SRA - NCBI",
      "url": "https://www.ncbi.nlm.nih.gov/sra/",
      "publisher": "NCBI",
      "year": null,
      "type": "Database",
      "topic": "research-tools",
      "summary": "NCBI SRA provides sequencing-study records and raw data.",
      "limitation": "Some human data require controlled access.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-088",
      "title": "NCBI dbGaP",
      "url": "https://dbgap.ncbi.nlm.nih.gov/home/",
      "publisher": "NCBI",
      "year": null,
      "type": "Database",
      "topic": "research-tools",
      "summary": "dbGaP links genotype and phenotype studies with controlled-access research data.",
      "limitation": "Study-specific approval and use restrictions apply.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-089",
      "title": "European Nucleotide Archive",
      "url": "https://www.ebi.ac.uk/training/online/courses/ena-quick-tour/what-is-ena/",
      "publisher": "EMBL-EBI",
      "year": null,
      "type": "Database",
      "topic": "research-tools",
      "summary": "EMBL-EBI introduces the European Nucleotide Archive's sequence holdings.",
      "limitation": "Public data and private member genomes require different handling.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-090",
      "title": "Refget Specifications",
      "url": "https://ga4gh.github.io/refget/",
      "publisher": "GA4GH",
      "year": null,
      "type": "Standard",
      "topic": "research-tools",
      "summary": "GA4GH refget supports unambiguous reference-sequence identifiers and retrieval.",
      "limitation": "Interoperability, not genetic interpretation.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-091",
      "title": "How to Download Records using the ENA Browser API \u2014 ENA Documentation 1 documentation",
      "url": "https://ena-docs.readthedocs.io/en/latest/retrieval/programmatic-access/browser-api.html",
      "publisher": "Project documentation",
      "year": null,
      "type": "API documentation",
      "topic": "research-tools",
      "summary": "ENA documents programmatic sequence-record retrieval.",
      "limitation": "Service limits and access conditions apply.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-092",
      "title": "Our products \u2013 GA4GH",
      "url": "https://www.ga4gh.org/our-products/",
      "publisher": "GA4GH",
      "year": null,
      "type": "Reference resource",
      "topic": "research-tools",
      "summary": "GA4GH catalogs genomic data, security and interoperability standards.",
      "limitation": "Record the specification version used.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-093",
      "title": "Quickstart Tutorial",
      "url": "https://starterkit.ga4gh.org/docs/getting-started/quickstart/",
      "publisher": "GA4GH",
      "year": null,
      "type": "Software",
      "topic": "research-tools",
      "summary": "GA4GH Starter Kit demonstrates genomic data-service implementations.",
      "limitation": "Production use needs independent security review.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-094",
      "title": "BLAST: Basic Local Alignment Search Tool",
      "url": "https://blast.ncbi.nlm.nih.gov/Blast.cgi",
      "publisher": "NCBI",
      "year": null,
      "type": "Software",
      "topic": "research-tools",
      "summary": "NCBI BLAST compares biological sequences with reference databases.",
      "limitation": "Similarity is not identity or clinical interpretation.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-095",
      "title": "Galaxy Hub",
      "url": "https://galaxyproject.org/galaxy-project/",
      "publisher": "Galaxy Project",
      "year": null,
      "type": "Software",
      "topic": "research-tools",
      "summary": "Galaxy supports web-based, reproducible biomedical analyses.",
      "limitation": "Sensitive data need an appropriately governed environment.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-096",
      "title": "BioStudies < The European Bioinformatics Institute < EMBL-EBI",
      "url": "https://www.ebi.ac.uk/biostudies/",
      "publisher": "EMBL-EBI",
      "year": null,
      "type": "Database",
      "topic": "research-tools",
      "summary": "BioStudies links data and supporting materials for biological studies.",
      "limitation": "Reuse rights and consent restrictions remain dataset-specific.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-097",
      "title": "Datasets - NCBI - NLM",
      "url": "https://www.ncbi.nlm.nih.gov/datasets/",
      "publisher": "NCBI",
      "year": null,
      "type": "Database",
      "topic": "research-tools",
      "summary": "NCBI Datasets packages genomes, annotations and metadata.",
      "limitation": "Record the accession and version.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-098",
      "title": "Ensembl",
      "url": "https://www.ensembl.org/",
      "publisher": "Ensembl",
      "year": null,
      "type": "Database",
      "topic": "research-tools",
      "summary": "Ensembl supplies genome annotation and comparative-genomics resources.",
      "limitation": "Assemblies and annotations change over time.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-099",
      "title": "UCSC Genome Browser",
      "url": "https://genome.ucsc.edu/",
      "publisher": "UC Santa Cruz",
      "year": null,
      "type": "Software",
      "topic": "research-tools",
      "summary": "UCSC supports genome visualization, track queries and coordinate conversion.",
      "limitation": "Assembly mismatches can invalidate comparisons.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-100",
      "title": "MetaboLights",
      "url": "https://www.ebi.ac.uk/training/online/courses/metabolights-quick-tour/what-is-metabolights/",
      "publisher": "EMBL-EBI",
      "year": null,
      "type": "Database",
      "topic": "research-tools",
      "summary": "MetaboLights holds metabolomics studies, raw measurements and metadata.",
      "limitation": "Study design affects comparability.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-101",
      "title": "PRIDE Archive",
      "url": "https://www.ebi.ac.uk/training/online/courses/proteomics-an-introduction/proteomics-resources-at-the-ebi/pride/",
      "publisher": "EMBL-EBI",
      "year": null,
      "type": "Database",
      "topic": "research-tools",
      "summary": "PRIDE archives mass-spectrometry evidence for proteins and peptides.",
      "limitation": "Identification confidence depends on methods and quality controls.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-102",
      "title": "PRIDE Archive API Guide",
      "url": "https://www.ebi.ac.uk/pride/ws/archive/v2/docs/api-guide.html",
      "publisher": "EMBL-EBI",
      "year": null,
      "type": "API documentation",
      "topic": "research-tools",
      "summary": "PRIDE documents project, file and metadata queries.",
      "limitation": "Observe service limits and dataset licensing.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-103",
      "title": "QIIME 2 Homepage",
      "url": "https://www.qiime2.org/",
      "publisher": "QIIME 2",
      "year": null,
      "type": "Software",
      "topic": "research-tools",
      "summary": "QIIME 2 provides reproducible microbiome and multi-omics analysis.",
      "limitation": "Results depend on sampling, controls and methods.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-104",
      "title": "Bioconductor - Home",
      "url": "https://bioconductor.org/",
      "publisher": "Bioconductor",
      "year": null,
      "type": "Software",
      "topic": "research-tools",
      "summary": "Bioconductor supplies open-source biological data-analysis tools.",
      "limitation": "Versions and dependencies affect reproducibility.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-105",
      "title": "Europe PMC",
      "url": "https://europepmc.org/RestfulWebService",
      "publisher": "Europe PMC",
      "year": null,
      "type": "API documentation",
      "topic": "research-tools",
      "summary": "Europe PMC documents publication and preprint search.",
      "limitation": "Distinguish preprints from peer-reviewed articles.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-106",
      "title": "REST API - Crossref",
      "url": "https://www.crossref.org/documentation/retrieve-metadata/rest-api/",
      "publisher": "Crossref",
      "year": null,
      "type": "API documentation",
      "topic": "research-tools",
      "summary": "Crossref exposes bibliographic metadata, identifiers and publication updates.",
      "limitation": "Verify important claims in the original source.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    },
    {
      "id": "dx-107",
      "title": "API reference",
      "url": "https://help.openalex.org/api/",
      "publisher": "OpenAlex",
      "year": null,
      "type": "API documentation",
      "topic": "research-tools",
      "summary": "OpenAlex supports discovery across works, authors, institutions and topics.",
      "limitation": "Discovery metadata does not establish scientific quality.",
      "doi": null,
      "checked": "2026-10-08",
      "verification": "Primary-source page or bibliographic record indexed; not a full-text quality appraisal."
    }
  ]
}